depression, which antidepressants have a low risk of sexual side effects? Fluoxetine (Prozac) >bupropion (Wellbutrin); sertraline (Zoloft). SSRIs Most at Risk for Causing Sexual Side Effects sertraline, and fluoxetine.9 The incidence of sexual dysfunction was similar between. Sexual dysfunction is a common side effect of antidepressants and can . the effects of sustained-release bupropion and sertraline on sexual. Agitation, insomnia, restlessness, weight loss. Current Efrect in Psychiatry. Some years later, Ferguson et al 17 in an 8-week double-blind study, also compared nefazodone with sertraline, this time among people who were dick medicine sexual dysfunction attributable sexuql sertraline. What are your concerns? The following antidepressants are reportedly the effec problematic:. Many adverse sexuxl, eg, hypertensive crisis, so rarely used in clinical practice; due to affinity for cholinergic and adrenergic receptors. Received Sep 8. The complete database of evidence-based questions and answers is copyrighted by FPIN. Erectile dysfunction medications can help men maintain an erection. Prozac, for example, has a much longer half-life than most antidepressants, which means the level of the drug remains consistent in your body for an extended period of time after you stop taking it. Phosphodiesterase 5 Inhibitor Use in Sexual Dysfunction A systematic review of randomized control trials found that phosphodiesterase 5 PDE5 inhibitors, such as sildenafil and tadalafil, improved erectile dysfunction better than placebo in male subjects with sexual dysfunction as a result of antidepressant treatment. Ther Adv Psychopharmacol. As stated earlier, the normal sexual response cycle consists of four successive phases: desire, arousal, orgasm, and resolution. Related coverage. Cochran Database Syst Rev. A randomized controlled trial. Bupropion as an antidote for serotonin reuptake inhibitor-induced sexual dysfunction. The drug is common in Australia dide Finland, but is not approved for erectile dysfunction natural treatment exercise for in the United States. South African Family Practice51 4 Are there any natural supplements or lifestyle practices I can use to decrease sexual side effects aide taking antidepressants? However, it makes sense that higher doses result in an increased risk of sexual side effects. If your doctor would prefer to stay on the same dose of your medication, you may be able to talk to them about taking periodic breaks or " drug holidays. Deciding when to take your medication will depend on many factors, such as your daily routine or other side effects you experience such as nausea, which may be reduced if you take your pill with food, or trouble sleeping. The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reuptake inhibitor: a double-blind placebo-controlled and randomized study. Strategies for managing antidepressant-induced sexual dysfunction: systematic review of randomized controlled trials. Mayo Clinic does not endorse any of the third party products and services advertised.