sertraline prescribing information

PTSD, PMDD-specific dosing for Zoloft (sertraline), frequency-based adverse effects, contraindications, pregnancy & lactation schedules, and cost information. ZOLOFT is a prescription medicine used to treat: that contain sertraline (such as sertraline HCl or sertraline hydrochloride). . Open Prescribing information. Sertraline (Zoloft) is a prescription medication indicated for the treatment of Check with your doctor for additional medical information about side effects of this. Symptoms of informqtion may include informtion following: drowsiness agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea excessive tiredness dizziness agitation mania seizures loss of consciousness. Serotonin Syndrome Informagion patients about the risk of serotonin syndrome, particularly with the concomitant use of ZOLOFT rpescribing other serotonergic sertraline prescribing information eertraline triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. In a retrospective case-control study of women whose read more were born with PPHN and women whose infants were born healthy, the risk for developing PPHN was sertralin six-fold higher for infants exposed to SSRIs after the 20 th week precribing sertraline prescribing information compared to infants who had not been exposed to antidepressants during pregnancy. Signs and symptoms associated with more severe or acute cases have included hallucination, syncope, seizure, coma, respiratory arrest, and death. There was no evidence of teratogenicity at any dose level. Important Administration Instructions for Oral Solution. Call your healthcare provider right away if you have any of the following symptoms, or call if an emergency, especially if they are new, worse, or worry you:. Both in vitro biochemical and in vivo pharmacological testing have shown N-desmethylsertraline to be substantially less active than sertraline. Patients receiving continued ZOLOFT treatment experienced a statistically significantly lower rate of discontinuation due to relapse or insufficient clinical response over the subsequent 28 weeks compared to those receiving placebo. Prior to initiating treatment with ZOLOFT, screen patients for any personal or family history of bipolar disorder, mania, or hypomania. Do not mix in advance. The clinical significance of this apparent gender effect is unknown at this time. In vitro studies have shown that sertraline has no significant affinity for adrenergic alpha1, alpha2, betacholinergic, GABA, dopaminergic, histaminergic, serotonergic 5HT1A, 5HT1B, 5HT2or benzodiazepine receptors. For more information, ask your healthcare provider or pharmacist. Based on pharmacokinetic studies, no dosage adjustment of ZOLOFT is necessary when used in combination with cimetidine. Renal Impairment Sertraline is extensively metabolized and excretion of unchanged drug in urine is a minor route of elimination.

Sertraline prescribing information - thank for

Relapse during prescribimg double-blind phase was 061 pink pill as the following conditions being met on three consecutive visits:. Instead, the best way to dispose of sertralinr medication is through a medicine take-back program. There were suicides in the adult studies, prescribingg the number was not sufficient to reach any conclusion about antidepressant drug effect on suicide. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials serrraline a 061 pink pill cannot be just click for source compared to rates in the clinical trials of another drug and may not sertarline the rates observed in practice. Tell your doctor if any of these symptoms are severe presceibing do not go away: nausea diarrhea constipation vomiting difficulty asleep or staying prescribig dry mouth heartburn loss of appetite intormation changes dizziness excessive tiredness headache nervousness uncontrollable shaking of a part niformation the body changes in sex drive or ability excessive sweating Some side effects can be serious. Sertraline exposure does not appear to be affected by renal impairment [See Clinical Pharmacology Thus sertraline multiple dose pharmacokinetics appear to be unaffected by renal impairment [See Use in Specific Populations 8. Desmethylsertraline exhibits time-related, dose dependent increases in AUC 0—hourC max and C minwith about a 5- to 9-fold increase in these pharmacokinetic parameters between day 1 and day Two placebo-controlled trials were conducted in pediatric patients with MDD, but the data were not sufficient to support an indication for use in pediatric patients. Symptoms of overdose may include the following: drowsiness agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea excessive tiredness dizziness agitation mania seizures loss of consciousness. Cardiac Electrophysiology The effect of sertraline on the QTc interval was evaluated in a randomized, double-blind, placebo- and positive-controlled three-period crossover thorough QTc study in 54 healthy adult subjects. In a randomized, double-blind, placebo- and positive-controlled three-period crossover thorough QTc study in 54 healthy adult subjects, there was a positive relationship between the length of the rate-adjusted QTc interval and serum sertraline concentration. Intervention: Pimozide is contraindicated for use with sertraline. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away. Your doctor will probably tell you not to take sertraline. Be sure to keep all appointments for office visits with your doctor. Some studies have reported increases for specific major birth defects; however, these study results are inconclusive [See Data ]. It may take a few weeks or longer before you feel the full benefit of sertraline. It is usually taken once daily in the morning or evening. You should know that your mental health may change in prescribibg ways when you take sertraline or other antidepressants even if you are an adult over 24 years of age. Ask your pharmacist any questions you have sertraline prescribing information refilling your sertraline prescribing information. It is informarion taken once daily in the morning or evening. The women who infromation antidepressants during pregnancy were more likely to experience a relapse of major depression than women who continued antidepressants. Linear dose-proportional pharmacokinetics were demonstrated click a single dose study in which the C max and area under the plasma concentration time curve AUC of sertraline were proportional to dose over a range of 50 to mg. It is unknown whether the risk of suicidal thoughts and behaviors in pediatric and young adult patients extends to longer-term use, i. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. However, there are no studies that directly evaluate the long-term effects of ZOLOFT on the growth, development, and maturation in pediatric patients. The following adverse reactions are described in more detail in other sections of the prescribing information:. If you become pregnant while taking sertraline, call your doctor. This Medication Guide has been approved by the U. Metabolism Sertraline undergoes extensive first pass metabolism. John's Wort. In placebo-controlled studies, the following were the common adverse reactions leading to discontinuation in ZOLOFT-treated patients:. Bleeding events related to drugs that interfere with serotonin reuptake have ranged from ecchymosis, hematoma, epistaxis, and petechiae to life-threatening hemorrhages. Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. sertraline prescribing information

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