Weight gain is one of the potential side effects of antidepressant use, is the most likely to lead to weight gain, while sertraline is least likely. New study links antidepressants and weight gain. in The BMJ found that one not-so-wanted side effect of antidepressants is weight gain. to gain at least 5 percent of their starting body weight than those who didn't take the. Weight gain is a possible side effect of nearly all antidepressants. However, each person responds to antidepressants differently. Some people gain weight.
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